Hi North, thank you for sharing.
1) As you know not only do O3s have the potential to modulate beta cells but there is a growing evidence that Vitamin D may also promote beta cell function. It is rather intriguing that the clinical case report you provided of the Type 1 Diabetic being administered both EPA/DHA Omega 3 but also Vitamin D. Such a single case does warrant a larger clinical study as some critics may just attribute the improvement in beta cell function to Honeymoon Period which is typical in onset soon after the diagnosis of Type 1 DM.
2) The commonest reason for a decrease in Insulin requirements for both Type1 and Type 2 DM is declining GFR. I am confident that with your meticulous care you have been monitoring your eGFR over time. If this is stable, that’s good. If there is a progressive decline, share this fact and the decrease in Insulin requirements with your Endocrinologist.
Another rare but very important etiology for decrease in Insulin requirements in Type 1DM is declining adrenal function and the development of Addison’s Disease which may Co-exist with Type 1 DM as part of an Auto-Immune Polyglandular Syndrome. This is also something that your Endocrinologist can easily check for.
Other more obvious causes of decrease in Insulin requirements include stricter adherence to a healthier diet and increase in exercise regimen.
If the above are all excluded, than your suggestion of potential benefit of V is more valid. Although I have no supportive data to quote by recall, I do believe that benefit of immuno-modulation may be greater the closer the intervention is to the onset of Type 1 DM. I believe that Jay Skyler out of Miami has studied twins with Type 1 DM where the unaffected twin with positive Islet Cell Antibodies became a subject for early drug intervention and study.
3) Finally, while ethically ( and rightly so ) I am unable to advise you of your treatment regimen, you did list two shots of N Insulin as your basal Insulin in addition to a newer analog for mealtimes. I am sure that you are aware that there are newer basal Insulin with less variability, with more stable PK and PD characteristics than N Insulin and with lower risks for hypoglycemia. In my opinion, it may be worth chatting to your Endocrinologist about this as well.
4) Finally, I enjoyed the rodent paper on O3 and the beta cell.
I do think that JT may find your background of great interest and may well reach out to you ! Your attention to detail and care is exemplary.
All the best.??
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