Replies to post #115577 on Amarin Corp Plc (AMRN)

[jessellivermore]

tasty....

Very well stated...excellent post...

:">) JL

[iwfal]

Boom. It really seems like the high TGs are the symptom of something else more important going wrong.

I agree that this is probably true - the APOC3 trials by IONS had surprising results on glucose control. Anyone who was paying attention was surprised that something that was expected to only directly influence lipids had a dramatic effect on glucose. (and I give the CEO a lot of credit for really focusing the Ph2s on this - so he'd know.)

And part of the reason I watch AMRN is because I am interested in this nexus - i.e. I will be interested in all the secondary endpoints for the Vascepa ph3.

That said, of course I think the trial has a LOT of risk. In a way very similar to ONTY - I think it likely it has some interesting benefit somewhere, but probably not enough on the primary endpoint (or has enough side effects to cause it not to be worthwhile.).

[rosemountbomber]

Good points about the fact that just looking at biomarkers only doesn't address what may be an underlying reason for that value.

As far as trigs go, with some exceptions in certain people, I find that trig levels can be more easily moved than many other biomarkers. Cutting out simple carbs, alcohol, and exercise can drop the trig numbers quite quickly. At least that has been my experience.