JL what are your thoughts in terms of what would happen in situations where we really need that inflammatory response To fight back that virus or bacteria or parasitic infection, do you think this drug is going to increase the rate of infection compared to the placebo ?as it has happens in case of a lots of other anti-inflammatory agents .Even in case of inhaled steroids there is increased rate of pneumonia even with the little exposure to systemic steroids in asthma or COPD.They are probably going to look at this in this study?