Thanks for the articles - the trial participation and patient availability is a big concern in many diseases as there are competing trials and patients are spread all over US - this is applicable for Rett as well.
Side question - "I have been particularly encouraged by breakthrough scientific advances that may ultimately enable therapeutics directly targeting the cause of Rett syndrome – insufficient MeCP2 protein (e.g., gene therapy, X-reactivation, protein replacement)"
If cause of Rett is insufficient MeCP2 protein - why A2-73 will be effective if it addresses homeostasis and not protein?