7th, I don't believe anyone minimizes the complexity of the Rett Syndrome as well as the similar complexity for AD and PD. The success of 2-73 may be wide in scope or narrow in application but I think most on this board believe there will be success and we will move progress in curing/treating these neurodegenerative diseases forward. As to the length of drug development and human trials on the graph, it certainly does not reflect the FDA's current plans under the 21st CCA. That has been significantly accelerated to bring safe and effective drugs to bare on the terrible diseases targeted.