Replies to post #108032 on Anavex Life Sciences Corp (AVXL)

[kld2]

And yet the entire AVXL narrative about homeostasis is built upon the generic S1R agonism mechanism. What about 2-73's action has been shown to be unique?...as far as I can tell just weaker S1R action and lower affinity. Not a great start.

Falconer, you're the Voice of Science for many on this board. I'd like to your hear rebuttal.

[Steady_T]

Ummm. I haven't seen detailed biochemical studies that show exactly how 2-73 is different in its activation, or weak activation as you say, of the Sigma-1 receptor.

I suspect that the complete picture of all of this class of drugs is not know. What is known is the side effect profile and efficacy profile of many of this class of drug.

So far, the efficacy and side effect profile of 2-73 is looking pretty good in the small number of people in the trials.

Arguing about the exact mechanism is entertaining but not likely to be definitive either way.