Replies to post #102975 on Anavex Life Sciences Corp (AVXL)

[amstocks82]

Misfolded proteins have a tendency to aggregate.

Amyloid beta "aggregates" in extracellular spaces outside of neurons forming amyloid plaques. Amyloid beta is formed from different sized fragments of a protein called "Amyloid Precursor Protein (APP)" which had “divided” into smaller fragments.

In healthy brain cells, amyloid beta is produced whenever APP is broken down. In healthy brains it is eliminated and does not accumulate.

One of the reasons that anti-amyloid beta treatments don't work is probably due to the fact that amyloid beta should always be present in healthy brain cells. It is part of the cellular "working". Drug treatments that target amyloid beta can therefore cause other neural diseases due to having too little amyloid beta.

Ideally, when the cells are healthy, amyloid beta is broken down and removed instead of accumulating.

You can read more about it by googling the topic. Also, the "Basic biology concepts for Alzheimer’s disease" above has more information.