Invest in a stock that you believe will develop into a solid business. For me it has been pntv for two years believing in the concept and now we are materializing the vision into the physical. I wholeheartedly believe this is developing into a solid business. Good businesses take time/years to realize. We've come a long way!
Alternately there are businesses built with piles of money showing off and they can burn out quickly. Lots of stocks like that which are not for me.