Replies to post #103254 on Amarin Corp Plc (AMRN)

[kvenne]

"There should be a world wide move to test for and tell people their APOE genotype. It's at least as important as blood type. But maybe more so, as it could inform your susceptibility to risk at a very early age, and tell you which dietary habits would promote longevity or not. Especially if you are an E4/E4 carrier."

Pyrr again you have to be corrected on your ill conceived understanding of what really matters. There should be a world wide test to tell people if they carry the DOPE genotype, and they should be instructed to stay away from message boards, or any pubic venue.

[jessellivermore]

Snips and snails....

So now it's all population genetics..and not dietary.

Sorry but this does not make any sense..

Some facts...First of all familial lipid disorders are well known to this board...KIWI has some form of familial hypercholesterolemia...Still KIWI holds fast to his daily EPA..

The fact is that Japanese who discontinue their traditional diet rich in EPA and low in CVD.. and begin eating "american" Rapidly assume the higher CVD risks of their american cousins. In fact Asian transported to the USA have higher rates of CVD and die younger than "white Americans"...

E4 genes effect the handling of trigs and VLDL in the liver. The general effect is raise trig, VLDL and remnants..EPA actually counterfeits these genetic effects (ask KIWI)...Yes the E4s are at greater CVD risk..but in an outcomes trial where there is just as many E4s in each arm...EPA will cut the CVD risk because it does counter the hepatic effect and also has other pleotropic (look it up) effects which are independent of the E4 genetic effect...

Do not make the KIWI mistake of thinking the trial arms are different in ways other than drug vs no drug...

":>) JL