Replies to post #93788 on Anavex Life Sciences Corp (AVXL)

[MycroftHolmes]

Re: Sigma/ROS stress.

I'll let the experts give the final word but my 2 cents:

Falcon,
What do you make of the conclusion

Conclusion
These experiments showed that s1R activity results in a dual regulation of the mitochondrial oxidative status: in basal conditions, s1R activity triggers a moderate ROS increase, putatively used as a physiological signal, while in pathological conditions, agonists promoted a marked anti-oxidant effect.

Under normal physiologic conditions, low-level oxidative stress (Reactive oxygen species - ROS) acts as a signaling pathway for autophagic processes that perform normal cleanup functions.

Pathologic conditions, or the agonizing of s1R, sets off a cascade which results in anti-oxidation effects. Thus, there is a "dual regulation" effect of assistance on both ends of the oxidation spectrum.

A2-73 reportedly only impacts cells under pathology and therefore acts as a reboot of anti-oxidation measures, stabilization of Ca+ flow, and the delay of apoptosis... among other things.

Not sure if that is what you were asking, hope that helps.

Cheers

Mycroft

[McMagyar]

ruby red! Fantastic! Way to break it down. Right on.
Just as the good Dr saying some patients were "Underdosed" gave way
to so many side conclusions, so does your spiking out this quote!

Of course they must have Pharmacokinetic Done! and with this,
the ACTION within the Body caused by A2-73 that CAUSES EFFECT!

NOW, We ARE..we HAVE..THE DRUG!
anavex now! for goodness sakes..

[falconer66a]

Post #93794 explains it well.

(Better than I could have.)