Replies to post #92766 on Anavex Life Sciences Corp (AVXL)

[MycroftHolmes]

RE: Study Response

"1. What are your thoughts on the strong 6 responders?"

I am not overly impressed with partial revelation of data. In addition 2 of the group had the bulk of their improvement in the first 5 weeks (a total of 24 days of treatment in that timespan) with gains of 4 and 6 points followed by another point or so gain (if I remember correctly).

I've seen this point on early response made a few different times but I tend to disagree; the pre-clinical literature is predictive of early impact in humans. Indeed, the mechanism of action lends itself to such an immediate result. My layman guess is that the full reaction to the agonist is slower than a pain killer but faster than a vaccine.

Such a reaction/improvement was seen after the first 5 weeks (though not statistically relevant in all categories). But this includes a 12-day washout period with no exposure to the drug, an important qualifier.

The 2 harder measures that I pay extra attention to are the p300 EEG wave "decision speed" and the "one-back" working memory. Both of these were among the biggest improvers after the first 5 weeks.

Knowing all of the above, I still almost fell off my chair when Missling announced 12 week trials for Rett and PD. I don't believe I need any other confirmation of HIS confidence in the speed of action.

To move forward in such a manner he must be very committed to either succeeding early or failing cheaply. That is why I tend to like his style.


Cheers

Mycroft