I see the action in the options as "covered calls" being sold by long stock holder's for premium collection to short position holders as portfolio Insurance to cap what could potentially be unlimited losses for the short position holders. If one followed the Sherlock Holmesian deduction of McMaguar of the Missling "underdosed" comments in the Noble Presentation one MIGHT recognize the reason for the heavy "out of the money" call option purchases.
On another note for many weeks or even months now the trading in AVXL has been "normal" largely devoid of fake VWAP walls although they do appear from time to time. I have tasked myself with the INEVITABLE task of watching Level 2 on AVXL for 2 years now. I know a "fake" VWAP; I also know a real one. IF ONE SEES "IN THE MONEY" OPTIONS ACTIVITY INCREASING those are long investors. There is no way in hell large one-off sweeps of "out of the money" call options are speculators, it is INSURANCE TO CAP LOSSES ON SHORT POSITIONS. DISCLOSURE: I AM HEAVY AVXL AND DERIVATIVES BUT I NEVER FLIPFLOP ON MY POSTS. EASY TO CHECK.