Canis. Overall survival is actually the easiest of the statistical parameters to calculate. Primarily, this is because of death is such a definitive unequivocal infallible event.
All you need to calculate Kaplan-Meier survival curves is the date the patient entered the trial, the date of last follow up or death and whether the patient was alive or dead at that date.
Progression free survival however is open to much more interpretation regarding whether or not the patient is coded as having progressed. Trial such as this will always compare the experimental arm with the control arm irrespective of whether or not patients received the experimental treatment in a crossover arm after progression.
As I have indicated in numerous previous post, the delay that we are seeing regarding events occurring is extremely positive feature the overall trial results.
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