I wouldn't be so confident that insurance companies will do the logical thing (covering an off-label use of a new drug), when it is obvious that in the long run it will save them money. I know of several new(at the time) drugs used by orthopedists that were both superior and cheaper than the old "gold standard" drugs, yet we had to jump through tedious hoops to get them authorized, or flat out didn't even try. They know that throwing up needless roadblocks will cause the applicant to not even try, not to mention the time the physician or staff have to put in for free. BTW, did you get the PM I sent last Friday?