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12/19/16 9:53 AM

#90175 RE: TC_Trader #90160

So this confirms that the company intends to conduct multiple combination trials with DCVax-L ... PLUS ... multiple trials with DCVax-Direct.

As previously announced, the Company is seeking to move forward with multiple clinical programs, involving both DCVax-L and DCVax-Direct. The Company is pursuing completion of the current Phase III trial of DCVax-L for Glioblastoma multiforme brain cancer as well as pursuing Phase II combination trials of DCVax-L and checkpoint inhibitor drugs, including the Phase II trial of DCVax-L and Pembrolizumab (Keytruda) for colon cancer that was previously announced. The Company is also pursuing multiple Phase II trials with DCVax-Direct for inoperable tumors, building upon the encouraging ongoing data from the Phase I trial, which included patients with 13 different types of cancers.