Replies to post #82970 on Anavex Life Sciences Corp (AVXL)

[powerwalker]

Thank you, blu. Great reading and explanation. Like this sentence the best:

Once homeostasis is achieved, the ER will get back to properly arranging and folding proteins, such as amyloid, Tau, and enzymes. Thus, it will no longer produce misfolded amyloid leading to plagues, no Tau tangles, nor enzymes that don't function properly.

[frrol]

Yes, and as you can see activating a receptor is tricky. It is not simply a switch you turn on, nor one you would necessarily want to leave activated all the time. This is why you'll often hear the term "modulation" of a receptor or its pathway rather than simple "activation" because you can easily over (or under) do it, or do it at the wrong time, or for too long, etc. Tricky. And playing with fire, as biological processes are tough to safely toy with.

We are trying to figure out if 2-73 activates the S1 and muscarinic receptors, and how to modulate the activation in the right way. It's one of many reasons why clinical research is so complex, takes so long, and why so much care is put into designing the trials. And with all the carefullness in the world, there is still some luck involved.