Agreed. I'm also speculating that some patients switched to the mono. Hence the switch in data time points. Also, with the difficulty seen obtaining patent on the combo therapies. I believe they would focus on the mono more.
We are already better than the soc. Safer and more peripheral benefits. Mood. Etc. if we just stabilize or see less of a decline. We are good to go. Homeostasis!!! Missling loves that word.
It would be great if they presented a graph with mono against historical controls of placebo and donepezil.
Commonly reported side effects of donepezil include: insomnia, diarrhea, and nausea. Other side effects include: fatigue, vomiting, muscle cramps, weight loss, anorexia, and ecchymoses. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to donepezil: oral tablet, oral tablet disintegrating
In addition to its needed effects, some unwanted effects may be caused by donepezil. In the event that any of these side effects do occur, they may require medical attention.
Severity: Moderate
If any of the following side effects occur while taking donepezil, check with your doctor or nurse as soon as possible:
More common:
Diarrhea
loss of appetite
muscle cramps
nausea
trouble in sleeping
unusual tiredness or weakness
vomiting
Less common:
Abnormal dreams
constipation
dizziness
drowsiness
fainting
frequent urination
headache
joint pain, stiffness, or swelling
mental depression
pain
unusual bleeding or bruising
weight loss
Rare
Black, tarry stools
bloating
bloody or cloudy urine
blurred vision
burning, prickling, or tingling sensations
cataract
chills
clumsiness or unsteadiness
confusion
cough
decreased urination
difficult or painful urination
dryness of mouth
eye irritation
fever
flushing of skin
frequent urge to urinate
high or low blood pressure
hives
hot flashes
increase in sexual desire or performance
increased heart rate and breathing
increased sweating
increased urge to urinate during the night
irregular heartbeat
itching
loss of bladder control
loss of bowel control
mood or mental changes, including abnormal crying, aggression, agitation, delusions, irritability, nervousness, or restlessness
nasal congestion
pain in chest, upper stomach, or throat
problems with speech
runny nose
severe thirst
shortness of breath
sneezing
sore throat
sunken eyes
tightness in chest
tremor
troubled breathing
wheezing
wrinkled skin
Incidence not known:
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