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frrol

10/22/16 12:02 PM

#78517 RE: LakeshoreLeo1953 #78510

Yes and the company is going to be accused of "data mining" in the Part B by the bears. That is typical and OK. As long as we use robust analytics in a large Phase 2/3, the bearish criticism is irrelevant. The "donepezil synergy" assertion last year and "no grouping" assertion this July lost the company some credibility in the market. They will survive it if the 52-week results show efficacy in the sub-pops. Objective results are what will rule the day.

McMagyar

10/22/16 6:05 PM

#78524 RE: LakeshoreLeo1953 #78510

this bigger population stigma is a joke..really just a joke.

say only 7 people go better out our 400..only 2%, why wouldn't you figure WHY those 2 % are getting better! The number of people in the TRIAL doesn't matter to a great degree..because we KNOW WHAT HAPPENS TO ALZHEIMER PATIENTS..they get WORSE AND DIE! Don't need 10,000 Patients in a study with 5,000 Blind Placebo to know that 5,000(really other than Anavex) 10,000 are going to get sicker and die! How about we bring Medicine INTO THE 21 st Century and QUIT letting people DIE because our scientific heads are buried too far up our pontifical netherlands.

We process 1 million times the information than we did 20 years ago..
Why will not medicine and dr.'s move along up the evolutionary scale
are redirect their efforts to saving people rather than letting people die?

Once upon a time this made sense..maybe even in some cases it still does..
but mostly BLIND PLACEBO GROUPS are for when you can not tell if something works..We know what that looks like for ALzheimers..
Honestly, I understand having multiple lines with other drugs..but a placebo group in an Alzheimer study for a drug that already shows EFFICACY and has an incredible safety profile..Anavexnow! and you take the placebo.