Thanks Sam. One note. From the SunTrust release:
"The criteria for early stop at the 80% target is less rigorous than the 60% interim criteria (early stop at 80% is triggered if p < 0.022), but still materially more onerous than the p < 0.05 criterion required for statistical significance. As such, we expect the DMC to recommend that REDUCE-IT continues until attainment of 100% of the target 1,612 primary events, which is estimated to occur in 2017, yielding publication of results in 2018."
What they don't make clear, is that because of all the peeks, for statistical significance at final (1,612) the results must even less than p < 0.05. Someone I believe posted the correct number but the approximation is something line p < 0.04. Now maybe that is not a big difference, but nevertheless one extra thing to think about.