"A statistically significant correlation was found between a higher
estimated TIL content and increased time to progression and overall survival. In addition, we were able to assess the proportion of shared TCR sequences between tumor and peripheral blood at time points before and after therapy, and found the level of TCR overlap to correlate with survival outcomes.
We determined that the estimated TIL content of pretreatment tumor directly correlated with survival and was predictive of which patients would benefit from the therapy. The fraction of TCR sequences
within tumors that can also be found systemically also correlated with clinical outcome and provided insight into the determinants of successful, antigen-specific, antitumor immune response."
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