"Goal was to establish dosage and safety for a larger trial - done!"
Exactly....I think this point needs to be harped on more. The fact 2-73 is safe is hugeeeeeee! We should have been green on that aspect alone. So many of these in trial drugs have major negative side affects.
Are you extrapolating the reported encouraging evidence that previously reported positive trends in certain cognitive and biologic measures persisted over a period of approximately 31 weeks to mean the the drug has been proven to reverse cognitive decline? Are you refering to the reports of patients doing well on the drug? The analysis of this trial was based on pooled data from a relatively small number of subjects receiving a variety of doses. There is no way a scientist can make definitive statements on any drug related improvement based on this trial - period.
There have been a number of treatments in the past that have reported dramatic improvements:
Novel Drug Therapy Immediately Reverses Alzheimer’s Cognitive Deficits