One danger is that on any release of good news short sellers will attack a stock, usually cordinated with nasty articles by the likes of AF. Such people care less about the science, they simply view it as a way to make free money. Sadly, such blatent manipulation seems to go undetected by the SEC. At least with AMRN having the Baker Brothers invested the ultimate outcome for them being long will ultimately be a positive one. Me thinks the Baker Brothers actually understand the science. They could care less if the stock goes from $3 to $1 or from $3 to $13. They are in it long term to make big money on their investment.