"#3 If we get acquired after FDA approval we can expect an offer much closer to $12-18 billion (2-3 times market share), not $6 billion."
12-18 billion? That's a bit of a stretch.
The general rule of thumb for biotech buyouts is that most companies are only willing to pay what they think they will make in sales in the first 5-year period that the drug goes to market.
I think 1-3 billion is a much more appropriate estimate, with 5-6 billion being the very high end of things.
That being said, that's still a lot of money for the shareholders if a buyout happened. I'm looking forward to it all going that smoothly.