Well a longer run for protection is always a good thing..but replacing Aricept outright would save everyone a lot of money. I am not sure of the short protection time line you give A2-73 w/o Aricept, and we have so much misinformation...So I will defer to George or someone else to confirm you time assesments for A2-73 protection. Would that include Breakthrough Designation? Orphan Status..etc.....