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kabunushi

06/16/16 10:37 PM

#64732 RE: beartrap12 #64727

Bear, really good points! Especially, I know from experience investing in other tiny companies trying to compete with the big boys that they are super vulnerable to the competition 'getting to' their key vendors or customers. It's worth a lot of consideration to be in a more secure position verses such vulnerabilities.
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Doktornolittle

06/17/16 9:08 AM

#64760 RE: beartrap12 #64727

"The good thing about this arrangement is that NWBO is not at the mercy of a company that may not be willing to work with their timeline and needs. So we don't have to worry about a manufacturer refusing to do what we need done when we need it done, and Linda can help oversee the quality of their work, as well."

"I can imagine what a nightmare it could have been for NWBO if BP or the shorts had yanked the strings of their manufacturer to turn them away at a critical moment. That kind of loyalty money can't buy."
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This is exactly how I see it. You look at the Phase V article, for example, and you know there is a force out there trying to ruin the company. Having mfg with a fully independent company just isn't an option, and never was if LP anticipated this kind of aggression.

That doesn't mean that any improper dealings between NWBO and Cognate are OK, but for me, it means I don't care about the small stuff.

As for why the two companies could not be one... I do think LP sees Cognate as the sure thing if immunotherapies are the future, while NWBO is the horse in the race, with an enormous possible payoff. I don't think that is a horrible attitude, I think it is just rational. Even from an ethical standpoint, if she can provide affordable mfg to immunotherapy companies, then she will have done something good. Pyrrhonian would gag at the sound of that given the apparent enormous cost per patient that Cognate has charged, but we do not know yet how much money went into automated mfg development, etc.. Again, I don't care about the small stuff, but the big stuff does matter, so I sure hope to hear some explanation for those costs someday soon.

How to rationalize the lack of transparency on the enormous $ to Cognate?

1) If LP spent a ton of $ on automated mfg development, and then such was not successful, that would look very bad. Not a great reason, but a reason.

2) Making such info public would help competitors strategize.
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maverick_1

06/17/16 1:49 PM

#64793 RE: beartrap12 #64727

MFG: Current INDEPENDENT validations and perspective buttressing those comments of Beartrap12 and iwasadiver

Surely, LP's life long obsession of being strategically independent achiever is seen in the astute distress purchase of Memphis, a new facility bought at Chapter 11 auction of GeneSys, followed by it's recently completed expansion as well as the early Summer 2015 commitment to Swanston, UK site mfg facility is backup to her Sept 2014 Mantra statement:"Going It Alone or Going Home".

Note there are a numerous nuggets found in the below links....

1. Larry Smith on PCT opers of CLBS (formerly Pyrrh's Neostem Buy@$5):

https://smithonstocks.com/caladrius-biosciences-the-business-model-is-intriguing-but-the-cash-position-is-weak-clbs-0-57-no-opinion-at-this-time/

http://www.caladrius.com/press-release/global-collaboration-and-license-agreement-with-hitachi-chemical/

2. UK Groundbreaking Nov 2015 with 2017 completion of ~$60+Mln COST of Catapult's NEW Regenerative Cell Mfg.

The Cell and Gene Therapy Catapult is part of a family of Catapults which are not-for profit, independent centres which connect businesses with the UK’s research and academic communities.

https://ct.catapult.org.uk/news-events-gallery/news/new-report-shows-capacity-capability-cell-gene-therapy-manufacturing-continues-increase-uk/

https://ct.catapult.org.uk/manufacturing/manufacturing-centre-status-updates/

We’ve chosen to build our £55m state-of-the-art Cell and Gene Therapy Manufacturing Centre in Stevenage, UK.

GE Healthcare Life Sciences CEO Kieran Murphy says: “The clinical science in cell and gene therapy is making significant strides, and there is no doubt about the consensus: this is set to revolutionise medicine.

“The toughest nut for cell therapy companies to crack is to scale-up approval, manufacturing and distribution of these therapies so they are affordable and accessible to patients globally; this manufacturing centre will help companies to crack that nut.

Hopefully everyone finds the above as reinforcing!

For reasons previously indicated, I was fortunate to have sold portfolio wide early Summer 2015 and over 85% of my NWBO position not far from highs and before Aug 2015 DCVAX L screening halt, and repurchased in the last week.... and adding.