doingmybest,
I know enough from research about what happens during activation and signaling to realize what I would try to do with the product at the right time for improved selection of activated DCs or perhaps even improving DC potency. This is one of several "light bulb turns on" moments I have had while doing basic research on cellular signaling and interactions. If there indeed is improved potency as suggested by the quotes referrenced recently on this blog, this might have first been caused by accident but I think NWBO and Cognate may have caught on quickly. Pure speculation but like I said, I know what I would have tried to do to tweak selection. I believe one of their patents actually gives a very nondescript hint by eliminating certain known activating agents for this process. Best wishes.
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