It stops the protein from Misfolding and then accumulating. Thereby filtering CSF. Like removing cars from a busy street before they crash into each other secondary to congestion.
the Sigma 1 Ligand which is called the "Chaperone" allows CNS Neurons to perform properly...Listen to Dr. McFarlane's Radio Interview..he outlines the Proteins..Tau and Amyloid..from what I understand it is the misfolding of these proteins that causes buildup..Anavex PREVENTS the Misfolding..and per our recovering AD Patients..Neuronal Cells may be brought back!