iclight,
Progression was inevitable for most if not all patients unfortunately. This has everything to do with understanding immune response times and cycles to stimuli. The spacing of the treatments is critical because the immune response is targeted, controlled and balanced while educated DCs remain on site or in L's case, also in circulation, which is not very long in either case. This response is not designed to be overwhelming or unbalanced, as some immunotherapies have proven to be, which tends to cause serious adverse events. Spacing and multiple injection sites are variables that appear to be critical factors with DC therapies and probably two of the main reasons for the pleasant surprise response seen in open label info among others already thoroughly discussed.
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