The most important issue to predict R-I failure/success has always been a good estimate of placebo rate. Now we know the approximate timing interim stop, say beginning of march to be conservative, estimating a fairly accurate placebo rate is that much more important. Some poster mentioned last week about a trial with hard MACE event rate of over 3% (please remind me what trial was that?). R-I includes both soft MACE and hard MACE, does anybody know the approximate ratio of hard MACE to soft MACE in other related trials?
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