Maybe you are right about the delay of Direct being so disturbing, but I don't see the L Phase 3 as being in a shambles.
Aside: I should not be talking about whether anybody should be invested right now or not. Easy enough to keep strictly to why I am invested, or not.
Further, the imminent catalyst that I think LP is planning on, in retrospect, is very likely the lifting of the screening hold. Fancier stuff could be in the works, but I am influenced by AVII's discussion about unplanned looks at efficacy. That they can't lead to any action by a company. The company / sponsor can't know the results of those looks. If there is a look right now it is probably to make a decision about Celldex and will likely have no effect on NWBO. That doesn't mean they won't have a scheduled look soon, or that somebody might do something out of the norm because efficacy is so fantastic... but in the normal scheme of things, I believe AVII, that any look now would not be allowed to benefit NWBO. Flipper knows so much more than I do that I will continue to listen to his perspective on the question, but I am influenced by AVII's recent discussion.