Replies to post #54412 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

How about this quiz:

1) What percentage of nGBM patients randomized into the main trial are psPD (this includes radionecrosis)?
a) 10%
b) 15%
c) 20%
d) 30%

2) How will these psPD patients affect the medPFS?
a) lower it
b) raise it. Most delayed psPD will not be misdiagnosed as progressive, and therefore remain in the main trial. IMHO.
c) do neither


3) Did Dr. Bosch's statement that pseudoprogression is wreaking havoc on trials refer to this p3 dcvax-L trial?
a) Yes
b) No
c) More likely referring to published trials with results.


4) Did the pI trial results for medPFS showing 24mth reflect a correction for psPD that will NOT be utilized in this p3 trial?
a) Yes
b) NO, because AVII was not the radiologist in the phase I/II trials, they diagnosed them stable disease.


5) Will Baseline 1 MRI be able to capture enough psPD patients to meet the 32 enrollment number for the psPD randomized arm?
a) Yes, and the diagnosis must be confirmed by baseline 2.
b) NO