Replies to post #68696 on Amarin Corp Plc (AMRN)

[sts66]

I think this topic may have been touched upon before, but this article is a nice summary - the first one which your link was based on they mix the use of "heart attack" and "heart failure", not clear to me exactly what they're claiming, but those are two different types of CVE - IIRC, some drug(s), maybe PSCK9's, appeared to increase risk of heart failure? Might be statins I'm thinking of, as they reduce the amount of COQ10, which your muscles, including the heart, need for proper mitochondria function.

http://www.express.co.uk/life-style/health/633160/Cholesterol-drug-statins-cause-heart-disease-experts

Now Professor Harumi Okuyama, whose team studied a series of more than 20 major research papers on the drugs, says they could cause heart disease.

Dr Okuyama, of Nagoya City University, Japan, said: “We have collected a wealth of information on cholesterol and statins from many published papers and find overwhelming evidence that these drugs accelerate hardening of the arteries and can cause, or worsen, heart failure. I cannot find any evidence to support people taking statins and patients who are on them should stop.”

The researchers say the hypothesis that statins protect the heart by lowering cholesterol is flawed and that high cholesterol is not necessarily linked to heart disease.

They also found statins have a negative effect on vital body processes linked to heart health.

They discovered patients taking the drugs were more likely to have calcium deposits in their arteries, a phenomenon directly linked to heart attacks.

This is because statins block a molecule needed for the body to produce a vital K vitamin, which prevents calcification of the arteries.

Dr Okuyama and his team say many earlier industry-sponsored studies, which show the benefits of statins, are unreliable.

They claim this is because they were carried out before new European regulations were introduced in 2004 which insisted on all trial findings, both negative and positive, being declared.

The study states that before these new rules came into effect “unfair and unethical problems were associated with clinical trials reported by industry-supported scientists”.

Dr Okuyama’s team looked at studies before and after 2004.

They found: “The epidemic of heart failure and atherosclerosis (hardening of the arteries) that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs. We propose that current statin treatment guidelines be critically re-evaluated.”