Replies to post #47827 on NorthWest Biotherapeutics Inc (NWBO)

[vator]

You heard it from the horses mouth or pulled out from somewhere else. CLDX in the opinion of the expert is more like apple juice. I am switching my funds over during the pre market session.

[Adam_Feuerstein]

A meta-analysis published in a PLOS journal doesn't scream credibility.

This is probably the most accurate paragraph from the study:

Although several early-phase clinical trials have demonstrated promising therapeutic outcomes to date, clinical immunotherapy trials for gliomas have not yet demonstrated objective proof of clinical trials for lacking the randomized studies, so limitations in our analyses should be considered in interpreting the results. Many intrinsic and extrinsic factors might influence the systemic review's reliability. First, no one trial has more than 100 patients per arm. Therefore, there is a lack of multinational, large-samples, multicenter clinical trials regarding DC cell therapy for HGG. Second, not all of the included studies reported clinical random allocation concealment, and in most cases, we collected data from the nonrandomized and randomized control or historical cohorts; thus, distribution and implementation biases may exist in our meta-analysis. Moreover, the analysis performed in this study was not based on individual patient data and was not subjected to an open external evaluation procedure. Maybe here one should refer to the proposed HGG-IMMUNO RPA model for use in future reports for relapsed patients treated with immunotherapy [11]. In addition, to maintain consistency during our systematic review, we selected only assessable patients for our analysis. These sampling factors may also introduce bias into our conclusions, for example considering the age-, degree of resection and therapy, gender- and disease-matched controls, and thus our analysis may have led to an overestimation of the treatment effects. However, we expect that our study will be valuable for the design of more comprehensive, larger, controlled clinical trials.