There's always risk. There's risk in the S & P 500. Risk/Reward to measure here with a long term view believing Anavex has the goods for greatness. I know many who gave up on PCYC, ACAD, JAZZ to name a few, sorry they did, they lost faith in the/a best stock now and for years. Personally, I'm long til I'm wrong or until the endgame. And unfortunately I've seen many leave here already as we're just getting 2nd inning started...........................$AVXL$