I think it is very bullish if a significant majority showed improvement at 12 weeks versus a simple majority at 5 weeks. What we don't know right now is:
1. The amount of improvement in the MMSE score (how many points?); 2. What the dosages of A2-73 were and what number of the patients were on Aricept + A2-73? Since the dosage was not optimized at 5 weeks, was the significant improvement at 12 weeks as a result of dosage optimization, continued improvement at the same dosage across all patients, or both?