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10/14/15 11:24 AM

#18999 RE: belgiumsui #18993

~ RGBP = Small Molecule Targeting Cancer Stem~Cell~Genes

Small Molecule targeting of the cancer stem cell is the process of “coaxing” the cancer stem cell to turn into a normal cell. Regen has identified and filed patents on a novel gene controlling the process of cancer stem cell differentiation.
Objective is to identify small molecules that can induce differentiation of cancer stem cells
High through-put screening identified 7 “hit” compounds
Currently in pre-clinical development
Initial indication is treatment of myelodysplastic syndrome
Additional indications include solid tumors and acute leukemia