~ RGBP = Small Molecule Targeting Cancer Stem~Cell~Genes
Small Molecule targeting of the cancer stem cell is the process of “coaxing” the cancer stem cell to turn into a normal cell. Regen has identified and filed patents on a novel gene controlling the process of cancer stem cell differentiation. Objective is to identify small molecules that can induce differentiation of cancer stem cells High through-put screening identified 7 “hit” compounds Currently in pre-clinical development Initial indication is treatment of myelodysplastic syndrome Additional indications include solid tumors and acute leukemia