Replies to post #20182 on Anavex Life Sciences Corp (AVXL)

[Mprush]

Circa, just wanted to say thanks for sharing your views and raising some excellent points here. Like others, I am beyond excited for November 7th, but we mustn't forget to examine all information with a critical lens as it is uncovered. A lot of smart people on this board, and for that I am grateful!

[TrueTrades]

Likewise, completely! Aside from those pesky details, I'm with you all the way. Again, that line of thinking soon-after the 22nd release is what got me looking at the (handy) dosing timeline to try and anticipate when a part B interim release might come. I, too, started looking at the wording of the 22nd PR vs the CT page for clues but had the poster to fall-back on and it kept me in-line.

My point holds regarding MMSE, though. That data is only collected in Part B (with comparison to baseline first possible at week 12), so the July 22nd PR had to be referring to Part B data when it asserted that MMSE scores were "consistent with the observed trend" in P300 numbers.

Well, if we consider "Cogstate scale changes" as one term and remove it the wording reads, "Preliminary measured Mini Mental State Examination (MMSE) are(is) consistent with the observed trend of the cognitive EEG/ERP effect". But that's just getting nit-picky speculative. As water under the bridge as it is, the critical eye does bear fruit with this current development! It almost seems, to me, that Missling WAS deliberately trying to hint in the 22nd PR. In the PR from June 30 announcing the release it states, "Changes in Electrophysiological Markers" in the poster title. Would you think "changes" indicates negative results? I did not analyze that one, but I learned quickly to carefully analyze the wordings. So when the CTAD info came and I read the title, I said, "YOU'VE GOT TO BE KIDDING ME! CAN HE DO THIS?". I'm still wondering if the SEC is going to scold him. And I don't think we will be getting anymore juicy PR hints...he'll just think of something else ;-)

An extra-special thanks to jason_luke for spotting that info before the change!!! I know there were some tweets and SA comments that preserved it, but I read it here first! Funny how I haven't seen any talk of the change on some sites, though....hmmmmm?

I was excited to see the ADCS-ADL results because I thought it might include all the surrogate endpoint-important caregiver and observational responses. But when I looked-into the test, it seemed geared (naturally?) for moderate-severe cases. I believe now though that there are different batteries and even custom trial-tailored sets, which I'm sure Missling would be all-over. So I let that one go.

I'm "cautiously optimistic :-D " about the 4X part. Lets see it duplicated on those ADAS-cog & MMSE charts first.

If this is the #1 board on iHub, it's because of the quality of posters, the IGGY crew notwithstanding...BARF! ;-) If this is the #1 board on iHub, what does that say about the company we keep? AVXL has not blown-up that much...yet! I'm proud to be on such a strong team and BDITG. (1 month gift subscription to the first freeber to guess that acro)

No..thank you!
§AVXL