A R/S isn't necessarily a bad thing... It depends what it's linked with... if it is linked with FDA approval that would be entirely different than if it was linked with new debentures. At this point I'm sitting on a sizable position (as in multi-millions of shares) and I personally have zero intention of selling prior to FDA approval.
if you think an r/s is comming get out before it happens, you can always buy back in after, the problem with holding thru an r/s is the week or two it takes to get your new shares. Your tied up yet the stock is free trading usually down.