I am surprised by your response. As you know, the half life of naloxone or naltrexone is largely irrelevant as these substances only come into play when abuse is undertaken and then the half life of such is not the same as the GI half life of the drugs if taken via oral administration. Further, as you know, in the case of Targiniq, the bioavailability after oral administration of noloxone is negligible, ie less than 2% by design. Thus I must conclude that such arguments are mere red herrings