When BPTH consistently produces results! Starting the last part of a Phase I study that should have been completed 2 years ago (it's not phase II, not by any definition) and getting orphan drug status over a 12 month period isn't enough! We need completed studies and a real phase II program with solid results before we see the pps we all hope for.
I also think investors want to see a company that can set and hit deadlines and leadership that takes accountability for their failures.