Replies to post #105126 on Innovation Pharmaceuticals Inc (IPIX)

[BonelessCat]

I think it's because Kevetrin also works with wild-type p53, which is dominant in both AML at UoB and the renal cancer types targeted at BI.

http://www.ncbi.nlm.nih.gov/m/pubmed/8123475/

[TheHound]

U turned out to be a real asset here. It's been fun watching you learn. One smart cat. Thank you! Ph2/3 or Ph2? I can't tell... Leo/Menon keep going back and forth. I'm happy with either.

[sox040713]

In almost all AML cases, the p53 gene is working. But the p53 proteins are always blocked by another protein, MDM2. Kevetrin targets the p53-MDM2 pathway in tumor suppression.

[frrol]

Clearly a ton. But a compromised p53 pathway doesnt necessarily start with a mutated p53 protein; over-expressed MDM2 would bollocks things up too. And Kevetrin addresses that it seems by stabilizing wild-type (the nonmutated p53)