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MontanaState83

05/02/15 11:34 AM

#48637 RE: Whalatane #48633

Kiwi - Thx again for the response. So, 20% could call a halt? Looking at the JELIS results, it would seem we could easily hit that at some point...
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ggwpq

05/02/15 11:55 AM

#48641 RE: Whalatane #48633

AK, the 20% efficacy doesn't correlate with late 2016 interim readout because lower efficacy leads to earlier interim. HD had a brilliant explanation and R-I interim calculation few months back. I hope he can repeat that exercise again here.

We know the following about R-I,

1) the 1612th event will occur end of 2017
2) the 967th event will occur sometimes in 2016
3) the lower the efficacy, the earlier the R-I interim