Rippy...how do you know when to take profits on something that may have a buyout that takes it to silver in a couple days....huh. Or if they develop GEN #2 through "X" and it's worth dollars! Some gurus say "let your winners run" if you are looking for the highest average gains in your portfolio over the long term. Saddest regret sometimes is pulling out too soon...lol (my apologies ladies).