I'm mostly curious how you got to 4% chance of futility. I have no feel for whether that is high, low or about right and could benefit from deeper understanding.
So, we get the "Upsize enrollment" outcome. Now 230 instead of 140. The bid / ask is 4.26 / 4.69 now, with the last trade at 4.36 (down 7.5%). So, if we get the full 15% downside, then we are looking at 3.8 - 3.90.