Replies to post #92869 on Innovation Pharmaceuticals Inc (IPIX)

[BobbyKIrk]

When is DF gonna give us the news on K ? It's Ctix time

[F1ash]

Wow, so they are going to start using it for their current clinical trials to help predict success. If they can tell in 16 hours which treatment will work, that has the potential to show Kevetrin's efficacy compared to other drugs. George should love it because they can even run combination drug testing.

[F1ash]

Hope you don't mind, I pulled some excerpts. Great find.
So I wonder what would happen if Kevetrin proved to be the most effective treatment, but there was no room in the clinical trial?


"Home
Cancer
February 26, 2015

By measuring how vigorously tumor cells turn on "self-destruct" signals when exposed to different cancer drugs, a novel lab test can predict within less than 24 hours which agent is most likely to work against a particular tumor, say researchers from Dana-Farber Cancer Institute.



A team led by Dana-Farber oncologist Anthony Letai, MD, PhD, reported in the February 26 online edition of the journal Cell that the test consistently predicted the "winner" among many drugs tested against a wide variety of cancer cells in the laboratory. In most cases, the answer emerged 16 hours after the anti-cancer compounds were mixed with tumor cells.

"This new technique represents a completely novel approach to precision medicine because we can test possible treatment directly on patient samples to guide cancer therapy," said Joan Montero, PhD, the first author on the report. "

[To infinity and beyond!]

Ladies and gentlemen- I hope you have all read this article carefully because IF it iturns out to be valid- and this is just the first report about this approach to cancer treatment- it will change everything.

AGAIN- any oncologists reading, please weigh in here.

But, this finding, that in LESS THAN A DAY you can predict the best chemo for a given pt, is astounding, and revolutionary.

Once the MTD is known then Kevetrin can be added to the mix somewhere in a Dana Farber lab. Yeah, yeah I know, these are for the FDA approved drugs- that makes perfect sense. But you can bet that once you have a completed Phase 1 that shows no horrible toxicity that anyone would want to know if Kevetrin- and all the other new chemo agents - will work, and they will be doing comparisons of newer drugs, unofficially or not.

It is a big IF. Will these results hold up?

It is also quite scary: I was reading about Aprea and their p53 drug, now in an ovarian cancer trial. Let's say they send over a sample of their new drug to Dana Farber. (Or maybe they can run the same tests in many labs around the world. How tricky, and how easily reproducible, is the process) And you know in a day how good K is, or how good the Aprea drug is, etc!?!!

First I have ever heard of anything like this. If this type of testing pans out it will be a total game changer for trials and treatment. Almost beyond belief.