Max dose Statin, unlikely to improve mortality in REDUCE-IT. Seems that max dose can cause deaths that are not CVE related! My take: The active arm with EPA will fair much better. Perhaps offsetting the effects of max dose statins!
How Effective Is Maximum-Dose Lipitor®? The TNT Heart Study
In the 2005 TNT study, 10,001 people with stable heart disease received either maximum-dose 80-mg Lipitor® or a standard dose of 10-mg Lipitor® daily.1 Maximum-dose Lipitor® reduced levels of harmful low density lipoprotein (LDL) to an average of 77 mg/dL. This represented a substantial reduction in LDL. In comparison, standard-dose Lipitor® reduced LDL to an average level of 101 mg/dL, which was also a good result.1
Over the five years of the study, 434 people (8.7%) in the 80-mg group experienced another cardiovascular incident (such as a heart attack or stroke) versus 548 people (10.9%) in the 10-mg group. This was an improvement of 2.2%, which meant 104 fewer cardiovascular incidents with maximum-dose Lipitor® compared with standard-dose Lipitor®. Twenty-nine fewer deaths from cardiovascular causes (126 versus 155) occurred with maximum-dose Lipitor®. These were also good results. However, this improvement in deaths was completely offset when 31 more people taking maximum-dose Lipitor® died from other causes. Overall, maximum-dose Lipitor® did not reduce the number of deaths in comparison with low-dose Lipitor®. In fact, the total number of deaths slightly increased in those taking maximum-dose Lipitor®. This startling fact means that maximum-dose Lipitor® increased the risk of death due to non-cardiovascular causes! This included 10 more deaths from cancer in the maximum-dose Lipitor® group versus the 10-mg group.1
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