Replies to post #22211 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Great!

Answer 1. Overcoming local and systemic tumor immune suppression is enough to completely eliminate cancer from the body over time (IMHO) if you are also using the full complement of tumor biomarkers. ICT-107 and other gene jockey methods not only do not use partial maturation to overcome local and systemic tumor and tumor microenvironment immune suppression, but they also hamstring themselves by only using a few random antigens when there are hundreds of tumor antigens, and even different antigens in different tumors throughout the body.

If DCVax-Direct used perfect partial maturation but only a few antigens, it would not be enough. If DCVax-Direct used all the antigens available in all the tumors, but it did not use perfect partial dendritic cell maturation, it would not be enough. Thankfully, DCVax-Direct did not skimp on its technology.


Answer 2. This technology was developed and perfected over many years. The DCVax-Direct preclinical and clinical trial pathology, observations and other results thus far present no reason to suggest the mechanism of action is significantly different than the MOA Bosch and Boynton perfected their patents upon, and that Liau and Prins helped develop through their work at UCLA.

Thus the title for the 2014 SITC abstract should, for all intensive purposes be claiming a result that is based upon the MOA that was/is being carefully perfected to the exact hour and dose -- even in the upcoming phase 2 multi-injection trial starting this fall. That perfection is being conducted based upon well documented advantages previously described and detailed by Doctor's Bosch and Boynton in their patents, by NWBIO in their literature, by other similar peer reviewed preclinical and clinical trials, including the recent phase 2 DCVax-Direct trial abstract published by UCLA -- and indirectly by many other dendritic cell preclinical and clinical trial efforts. (You may have noticed, I've been going to the trouble of reprinting and explaining more NWBIO literature today.) IMHO.