zum...
Thanks for posting...
The "trig issue" is perplexing. It seems that diabetic patients with elevated trigs are at greater risk for CVD events including death. The problem is lowering trigs with niacin or fibrates does not seem to confer risk benefits or effect mortality. There could be several explanations of why this is so.
Elevated trigs might lead to a condition that once established will continue even if the trigs are lowered to normal. Sort of like getting lung cancer and then quitting smoking.
The trials may be flawed as ACCORD, AIM and THRIVE are, and on closer inspection, do not really address the issue of trig lowering.
Most trig measurement are made on fasting subjects, and fasting trig levels may not be the culprit. Perhaps trigs are like blood sugar, and the peak levels reached after eating are the important measurement and not the fasting levels. Recent studies reported in the NEJofM...measured peak levels after eating and risk factors may be related to them.
IMO, Trig results are a leaky boat, and we should not be basing our hopes on them..
":>) JL
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