Thanks F3tt3f. That is exactly my view. The MRIs are spaced 2 months apart, so if they miss spotting progression on the first one, and the patient doesn't starts to exhibit decline symptoms before the next one, then they might not catch progression in time to help. They keep you on the same vaccine schedule, so let's say you had your vaccine scheduled for Tuesday, but you don't reach your PFS endpoint (according to the MRI) by Wednesday, then I believe you have to wait for your next shot to get the correct vaccine, assuming it's safe to give it to you at that point. We don't know his exact situation so we can't be sure if he received his crossover to the correct vaccine (switch is made in the lab, no one knows who gets what). However, since his speech became affected a second time, so we know the disease was present. He may have been on heavy steroids to help with the swelling, and the dr./hospital may have made the decision not to give him further injections because of his decline state. Who knows. The crossover window for hope closes very quickly, and it is largely determined by the patients current condition, when PFS endpoint is caught and the injection schedule they're on. So sadly, unless the timing works perfectly, placebo patients could miss their crossover usefulness window.
As for this case, others can formulate their own opinions or not, but in my mind it's clear to me that he received the placebo. On the first phase 19 of 20 patients lived longer than the average of the SOC. If I were to base my opinion on that alone, it confirms it for me.
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