The PDUFA date for Ligand Pharmaceutical's (LGND) CE Melphalan is Tuesday, September 30. The NDA was submitted by development and commercial partner Spectrum Pharmaceuticals (SPPI -0.9%). Captisol-enabled Melphalan is free of propylene glycol, which is associated with renal and cardiac side effects. Melphalan is a myeloablative therapy that is used prior to autologous stem cell transplantation